ODCs

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4 OMIM references -
3 associated genes
26 signs/symptoms

COMMON GENES: 2
PROTEIN INTERACTIONS: 2
COMMON SIGNS: 10

1 OMIM reference -
3 associated genes
25 signs/symptoms

Familial thrombocytosis

Polycythemia vera


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	JAK2 THPO	(0.66) (0.62)	MPL MPL

Citations in the biomedical literature:

Familial thrombocytosis		Polycythemia vera
	Synonym(s): - Familial thrombocythemia - Hereditary thrombocythemia		Synonym(s): - Acquired primary erythocytosis - Erythremia - Osler-Vaquez disease - PV - Polycythemia rubra vera - Vaquez disease

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): (no data available)		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: variable Average age of death: normal Type of inheritance: sporadic

	External references: 4 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: D011087


COMMON SIGNS	- Acute leukemia - Arterial embolism / thrombosis - Dizziness - Facial pain / cephalalgia / migraine - Myelodysplastic syndrome - Pruritus / itching - Splenomegaly - Transient cerebral ischemia / stroke - Venous thrombosis / phlebitis / thrombophlebitis - Weight loss / loss of appetite / break in weight curve / general health alteration

Familial thrombocytosis		Polycythemia vera
	Very frequent - Autosomal dominant inheritance - Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding - Platelet disorders / thrombopathies - Platelets shape anomalies Frequent - Acute ischemia of the lower limbs - Acute ischemic syndrome - Hyperhidrosis / increased sweating - Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness - Thoracic / chest pain Occasional - Abnormal visual field / hemianopsia / hemianopia / scotoma / visual peripheral rim - Early death / lethality - Elocution disorders / dysarthria / dysphonia - Myeloproliferative syndrome / chronic leukemia - Pulmonary hypertension - Seizures / epilepsy / absences / spasms / status epilepticus - Spontaneous abortions		Very frequent - Acute abdominal pain / colic - Angor pectoris / myocardial infarction - Chronic arterial hypertension - Ecchymoses - Epistaxis / nose bleeding - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Gingivorrhagia / gingival bleeding - Hepatomegaly / liver enlargement (excluding storage disease) - Tinnitus Frequent - Articular / joint pain / arthralgia - Asthenia / fatigue / weakness - Respiratory distress / dyspnea / respiratory failure / lung volume reduction Occasional - Claudication / pain on mastication / while chewing - Portal hypertension